Stromal Cell–Derived Factor-1 Confers Protection Against Myocardial Ischemia/Reperfusion Injury Role of the Cardiac Stromal Cell–Derived Factor-1 –CXCR4 Axis
نویسندگان
چکیده
Xiaofeng Hu, Shujing Dai, Wen-Jian Wu, Wei Tan, Xiaoping Zhu, Jingyao Mu, Yiru Guo, CXCR4 Axis − α Derived Factor-1 − Ischemia/Reperfusion Injury : Role of the Cardiac Stromal Cell Confers Protection Against Myocardial α Derived Factor-1 − Stromal Cell Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2007 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.106.672451 2007;116:654-663; originally published online July 23, 2007; Circulation. http://circ.ahajournals.org/content/116/6/654 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org/content/suppl/2007/07/16/CIRCULATIONAHA.106.672451.DC1.html Data Supplement (unedited) at:
منابع مشابه
The stromal cell-derived factor-1/CXCR4 axis in cardiac injury and repair.
Chemokines are chemotactic cytokines that direct cellular migration through interactions with their cognate chemokine receptors. Most chemokines are not expressed in the normal myocardium, but are up-regulated and secreted in the infarcted heart (1), where they play an important role in leukocyte recruitment (2). Stromal cell– derived factor SDF)-1/CXCL12 and its main receptor CXCR4 are a hemok...
متن کاملStromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps
Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R injury in ischemic free flaps. Free flaps that underwent ischemia for 3 h were...
متن کاملStromal cell-derived factor-1 (SDF1)-dependent recruitment of bone marrow-derived renal endothelium-like cells in a mouse model of acute kidney injury
Ischemic acute kidney injury (AKI) is the most key pathological event for accelerating progression to chronic kidney disease through vascular endothelial injury or dysfunction. Thus, it is critical to elucidate the molecular mechanism of endothelial protection and regeneration. Emerging evidence indicates that bone marrow-derived cells (BMCs) contribute to tissue reconstitution in several types...
متن کاملHypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression.
Myocardial infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recruitment of exogenously administered progenitor cells limits the effectiveness of cardiac cell therapy. Recent reports indicate that interactions between the CXC chemokine stromal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the ischemia-induce...
متن کاملCxcr4 expression is associated with time–course permanent and temporary myocardial infarction in rats
Objective(s): Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression of its receptor "CXCR4" on the surface of various cells. The aim of this study was to evaluate the expression pattern of CXCR4 in peripheral blood cells following time-course permanent and temporary ischemia in rats. Materials and Methods: Fourteen male Wist...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007